Luca Vago, M medicine .D., Ph.D., Serena Kimi Perna, M.D., Monica Zanussi, B.Sc., Benedetta Mazzi, B.Sc., Cristina Barlassina, B.Sc., Maria Teresa Lupo Stanghellini, M.D., Nicola Flavio Perrelli, B.Sc., Cristian Cosentino, B.Sc., Federica Torri, B.Sc., Andrea Angius, Ph.D., Barbara Forno, M.D., Monica Casucci, B.Sc., Massimo Bernardi, M.D., Jacopo Peccatori, M.D., Consuelo Corti, M.D., Attilio Bondanza, M.D., Ph.D., Maurizio Ferrari, M.D., Silvano Rossini, M.D., Maria Grazia Roncarolo, M.D., Ph.D., Claudio Bordignon, M.D., Chiara Bonini, M.D., Fabio Ciceri, M.D., and Katharina Fleischhauer, M.D.: Lack of Mismatched HLA in Leukemia after Stem-Cell Transplantation Transplantation of hematopoietic stem cells from a haploidentical family members donor who all shares only 1 HLA haplotype with the recipient is a potentially curative option for patients with high-risk hematologic cancers who lack an HLA-matched donor.1-3 The major limitation of this strategy is the threat of severe graft-versus-sponsor disease , that may derive from alloreactions mediated by donor T cells against the recipient’s unshared HLA haplotype.4,5 The efficacy and feasibility of infusions of haploidentical donor T cells have already been founded,6-8 and new immunosuppressive drugs have allowed for the transplantation of haploidentical grafts without depleting them of T cells.9,10 The infusion of donor T cells promotes rapid reconstitution of the disease fighting capability after transplantation.6,8 In addition, the graft-versus-leukemia effect mediated by such infusions is an effective type of immunotherapy for hematologic cancers.11 However, relapses still occur, and the mechanisms involved in such relapses remain elusive.
Simultaneously, that recipient’s coregistered donor donated a kidney to some other recipient at the same medical center. At the right period, the APD registry included just three potential recipients with blood group B, all of whom were as well highly sensitized and had donor-specific antibodies that were too high to allow them to receive a transplant from this donor. Transplantation 5 Since no matches for the bridge donor were found during the next three months, the APD contacted the Incompatible Kidney Transplantation Program at Johns Hopkins Hospital in Baltimore, a single-center registry.