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As the disease progresses, the result of oral medications may not last as long and can cause increasing side effects. Sufferers with advanced Parkinson’s disease may encounter fluctuations between periods of poor mobility or slowness and intervals when disease symptoms are well controlled. The loss in mobility or slowness/stiffness and periods of great symptom control are referred to as off period and on time, respectively. When off time increases, a patient’s on time progressively shortens. Additionally, many patients experience dyskinesias, which are involuntary movements associated with treatments used to manage Parkinson’s disease. Some of these involuntary actions can bother sufferers and make it difficult to perform activities.Orthostatic hypotension becomes more common as people grow older, Gibbons said. By enough time people are in their 60s or 70s, between 5 to 10 % will have developed the condition, he added. In the study, researchers reviewed the medical information of 230 individuals who underwent testing in 2002 and 2003 to see if their bodies were correctly regulating their blood pressure and heart rate. Ten-year follow-up data was designed for 165 of these social people. In the 10-year follow-up group, 48 started out with delayed orthostatic hypotension and 42 have been identified as having full-fledged OH, the study said.