Jury From Whether Saturated Fat Is Harmful to You Still, Researchers Say: – TUESDAY, Aug. 11, 2015 – – A fresh review suggests that saturated fats, like those within many milk products and meat, may not be the big contributors to cardiovascular disease or early loss of life that many think they are read more . However, the Canadian experts who did the review did look for a very clear link between heart problems and trans fats, which are located in processed foods such as snacks highly, margarine and baked items. ‘Not all the research we looked at reached the same bottom line, but generally what we found is that the association between an increased consumption of trans fat and a higher risk for heart disease and [early] loss of life was extremely consistent,’ said study author Russell de Souza.
All individuals in the ALN-TTR02 trial were male, since the protocol excluded females with childbearing potential in this early-phase study involving healthy volunteers. At study entry, serum transthyretin levels were lower in patients with transthyretin amyloidosis than in healthy volunteers modestly, a discovering that was consistent with reviews showing lower transthyretin amounts in sufferers with transthyretin amyloidosis than in either asymptomatic disease carriers or healthful controls.36 Efficacy ALN-TTR01 After an individual dose of ALN-TTR01, no significant differ from pretreatment baseline levels was seen in serum transthyretin levels, as compared with the placebo group, at doses of 0.01 to 0.7 mg per kilogram.