Jun-ichi Nishimura, M.D., Ph.D., Masaki Yamamoto, M.D., Shin Hayashi, M.D., Ph.D., Kazuma Ohyashiki, M.D., Ph.D., Kiyoshi Ando, M.D., Ph.D., Andres L. Brodsky, M.D., Ph.D., Hideyoshi Noji, M.D., Kunio Kitamura, M.D., Ph.D., Tetsuya Eto, M.D., Toru Takahashi, M.D., Masayoshi Masuko, M.D., Ph.D., Takuro Matsumoto, M.D., Yuji Wano, M.D., Tsutomu Shichishima, M.D., Ph.D., Hirohiko Shibayama, M.D., Ph.D., Masakazu Hase, Ph.D., Lan Li, M.D., Krista Johnson, M.Sc., Alberto Lazarowski, Ph.D., Paul Tamburini, Ph.D., Johji Inazawa, M.D., Ph.D., Taroh Kinoshita, Ph.D., and Yuzuru Kanakura, M.D., Ph.D.: Genetic Variants in C5 and Poor Response to Eculizumab Paroxysmal nocturnal hemoglobinuria arises as a consequence of clonal expansion of hematopoietic stem cells that have acquired a somatic mutation in the gene encoding phosphatidylinositol glycan anchor biosynthesis class A .1-3 The resulting hematopoietic cells are deficient in glycosylphosphatidylinositol-anchored proteins, including the complement regulatory proteins CD55 and CD59; this makes up about the intravascular hemolysis that is the primary clinical manifestation of PNH.4-6 PNH frequently develops in colaboration with disorders involving bone marrow failing, particularly aplastic anemia.‘Their work is vital. And their attempts will benefit children and families for years to come.’ Seven-year-previous Michael Andrews is a cancer tumor survivor who individually thanked Christine Wandzura for the support from the KCCFA for kids like him. He benefitted from the use of experimental therapies in his battle with neuroblastoma four years ago. Says his mother, Lisa Colford, ‘I don’t also want to think of where we’d be if researchers hadn’t come up with new drugs for Michael. It’s great to know that these kinds of breakthroughs will continue for children facing battles with cancers right here at the Alberta Children’s Hospital.’.. ACS revises guideline formation process for cancer screening New effort prioritizes transparency, consistency and rigorThe American Tumor Society has revised its guideline formation process to achieve higher transparency, consistency, and rigor in creating guidance about cancer screening.