Dopamine also stimulates dopaminergic receptors, resulting in a proportionately greater upsurge in splanchnic and renal perfusion, and it could facilitate resolution of lung edema. 5 Thus, norepinephrine and dopamine may have different results on the kidney, the splanchnic region, and the pituitary axis, but the clinical implications of the differences are uncertain still. Consensus guidelines and professional recommendations suggest that either agent can be utilized as a first-choice vasopressor in sufferers with shock.6-8 However, observational studies show that the administration of dopamine may be connected with rates of death that are higher than those associated with the administration of norepinephrine.3,9,10 The Sepsis Occurrence in Acutely Ill Patients study,3 which involved 1058 patients who have been in shock, showed that administration of dopamine was an independent risk factor for death in the intensive care unit .Today which is composed mainly of processed and unhealthy food The reason being of the dietary plan we enjoy. Thus, the effect is a higher incidence of colon problems from constipation to cancer of the colon. This is specifically the key reason why many companies are providing their own colon cleansing product claiming to greatly help in preventing these colon complications. Advocare Cleanse is one of the most popular colon cleaning systems that state to completely clean up the colon and at the same time help with weight loss.