But more youthful individuals had a shorter imply and maximum duration than older individuals for both methotrexate and oral steroids . Certified from medwireNews with permission from Springer Healthcare Ltd. All privileges reserved. Neither of these parties endorse or suggest any commercial products, services, or equipment.. Age at starting point influences juvenile dermatomyositis course By Lynda Williams, Senior medwireNews Reporter Children identified as having juvenile dermatomyositis at age 3 years or earlier have milder symptoms than sufferers with later onset, research suggests.The authors vouch for the fidelity of the report to the process and for the precision and completeness of the info and the analyses. Patient Selection We enrolled consecutive individuals, 18 years or older, with left-sided, native-valve infective endocarditis and a high risk of embolism. For all patients with suspected infective endocarditis, blood cultures were attained and transthoracic echocardiography was performed within 24 hours after hospitalization. Patients were eligible for enrollment if they had received a diagnosis of definite infective endocarditis based on the modified Duke requirements10 and had severe mitral valve or aortic valve disease and vegetation with a size greater than 10 mm.