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Mupirocin and chlorhexidine are considered to be relatively safe. Nevertheless, since S. Aureus strains may become resistant to mupirocin, we suggest restricting the use of this agent to known carriers who are in risk for infection.28 For screening purposes, concern should be directed at tests with high specificity, thus limiting the true number of false excellent results and the unnecessary use of mupirocin and chlorhexidine. The prevalence of methicillin-resistant S. Aureus carriage in the Netherlands is only 0.03 percent.29 Although this trial was designed to recognize and eradicate both methicillin-resistant and methicillin-sensitive S.